Research partially funded by the JKTG Foundation recently appeared recently in the Bulletin of Mathematical Biology.
The research, Intermittent Hormone Therapy Models Analysis and Bayesian Model Comparison for Prostate Cancer, includes work by Heiko Enderling, Ph.D., a researcher with whom JKTG has worked on several projects.
As described in the published abstract, first-line therapy for prostate cancer includes androgen deprivation therapy (ADT), depriving both the normal and malignant prostate cells of androgens required for proliferation and survival.
In recent years, intermittent ADT has been proposed as an alternative to continuous ADT. Several mathematical models with different biological resistance mechanisms have been considered to simulate intermittent ADT response dynamics.
The research compares 13 intermittent dynamical models and assess their ability to describe prostate-specific antigen (PSA) dynamics.
Featured news
Targeting effective treatments for triple-negative breast cancer
The JKTG Foundation recently awarded funding to Laura Heiser, Ph.D., Associate Professor and Vice Chair of Biomedical Engineering at the Oregon Health & Science University (OHSU) School of Medicine, to develop a prototype multiscale model designed to predict therapeutic responses of tumor ecosystems – a new frontier in breast cancer research.
JKTG Foundation targets effective treatments for triple-negative breast cancer
The Jayne Koskinas Ted Giovanis Foundation for Health and Policy (JKTG Foundation) today announced funding to develop a prototype multiscale model designed to predict therapeutic responses of tumor ecosystems – a new frontier in breast cancer research.
Ted’s Take: There are no stakeholders, it’s just US
The word “stakeholder” really bothers me particularly in the healthcare space. I’m struck by a quote by Ken Burns.
“The thing that I’ve learned is that there is no ‘them.’ This is what everybody does: make a distinction about ‘them.’ It’s just ‘us’.”
Jayne Koskinas Ted Giovanis
Foundation for Health and Policy
PO Box 130
Highland, Maryland 20777
Media contact: 202.548.0133