Research & Analysis

Tenascin-C activation of lung fibroblasts in a 3D synthetic lung extracellular matrix mimic
Appears in Advanced Materials

Triple-negative breast tumors contain heterogeneous cancer cell-dependent collective and disseminative invasion programs
Appears in Oncogene

Spatial analysis of nanopartical distribution in human breast xenografts reveals nanoparticles targeted to cancer cells localized with tumor-assisted stromal cells
Appears in Nanotheranostics

Live cell lineage tracing of dormant cancer cells
Advanced Healthcare Materials

Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin
Published in the journal Science Translational Medicine

Intermittent Hormone Therapy Models Analysis and Bayesian Model Comparison for Prostate Cancer
Published in the Bulletin of Mathematical Biology

Perspective: Materials-driven approaches to understand extrinsic drug resistance in cancer
Published in the journal Soft Matter
This piece sets the stage for collaborative work that JKTF Foundation funding helped spark among researchers

Agent-based-models help interpret patterns of clinical drug resistance by contextualizing competition between distinct drug failure modes
Published in the journal Cellular and Molecular Bioengineering

Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach
Published in the journal Scientific Reports

A common goal to CARE: Cancer Advocates, Researchers and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases
Published in npj| Breast Cancer

A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling
Published in iScience

Predicting patient-specific response to adaptive therapy in metastatic castration-resistant prostate cancer using prostate-specific antigen dynamics
Published in Neoplasia

Supporting computational apprenticeship through educational and software infrastructure: A case study in a mathematical oncology research lab
Published in PRIMUS

Intermittent hormone therapy models analysis and Bayesian model comparison for prostate cancer
Published in Bulletin of Mathematical Biology

Post-hypoxic cells promote metastatic recurrence after chemotherapy treatment in TNBD
Published in Cancers

Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies
Published in the journal Science Direct

Errors in papers that find hydroxychloroquine to be effective against COVID
Published on Academia.edu

Nanoparticle interactions with immune cells dominate tumor retention and induce T cell-mediated tumor suppression in models of breast cancer
Published in Science Advances

ORGDYN: Feature and model based characterization of spatial and temporal organoid dynamics
Published in Bioinformatics

Improving quality measurement: Design principles for quality measures
Published in the Journal of Ambulatory Care Management

*E-cadherin is required for metastasis in multiple models of breast cancer
Published in the journal Nature
*conducted by JKTG-supported researchers

Measuring the quality of health care in the US: Why we are failing and what we can do about it
Published by JKTG Foundation

Problematic risk adjustment in national healthcare safety network measures
Published in the American Journal of Medical Quality

Prediction of bone metastasis in inflammatory breast cancer using a Markov chain model
Published in The Oncologist

Learning-accelerated discovery of immune-tumour interactions
Published in the journal Molecular Systems Design & Engineering

A review of cell-based computational modeling in cancer biology
Published in JCO Clinical Cancer Informatics

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
Published in Nature Communications

A software tool for the quantification of metastatic colony growth dynamics and size distributions in vitro and in vivo
Published in PLOS | ONE

Temperature-controlled power modulation compensates for heterogeneous nanoparticle distributions: A computational analysis for magnetic hyperthermia
Published in the International Journal of Hypothermia

PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems
Published in PLOS | Computational Biology

Will Hospital Peer Grouping by Patient Socioeconomic Status Fix the Medicare Hospital Readmission Reduction Program or Create New Problems?
Published in the Joint Commission Journal on Quality and Patient Safety.
Related journal editorial can be read here.

Are We Confident of Across-Hospital Mortality Comparisons?
Published in the American Journal of Medical Quality

Inappropriate Statistical Model and Data Issues Lead to an Invalid Conclusion
Published on Academia.edu

Comparing the Value of Nonprofit Hospitals’ Tax Exemption to Their Community Benefits
Published in The Journal of Health Care Organization, Provision, and Financing

JKTG Foundation Comments on CMMI Experimental Payment Models

JKTG Foundation Comments on Medicare 5-Star Rating System

JKTG Foundation Comments on IPPS Proposed Rule

Quantifying the Impact of Socio-Economic Status on Quality Measures
Published on Academia.edu

An Analysis of the Medicare Hospital 5-Star Rating and a Comparison with Quality Penalties

ACA’s Preclusion of Appeals

Foundation Comment Letter on Part B Drug Payment Model Proposed Rule

Composite Measures of Health Care Provider Performance: A Description of Approaches
Published by The Milbank Quarterly, Vol. 93, No. 4, 2015 (788-825)

Foundation Comment Letter on Medicare Comprehensive Care for Joint Replacement

Foundation Q&A: Can Socioeconomic Status (SES) Payment Adjustments Improve Hospital Performance?

Analysis | Value Based Purchasing Rewards and Penalties
(external link)

Analysis | Are HospitalCompare Mortality Rates Useful?
(external link)

Study | NASI Integrated Delivery Networks: In Search of Benefits and Market Effects
(external link)

VIDEO + Materials | ECRI Partnership for Health IT Patient Safety Forum
(external link)

Analysis | Length of Stay and Hospital Acquired Infections

Transcript: Wall Street comes to Washington

Report: Washington D.C. health market analysis

Big Data — What Is It and What Use Is It?
Published in the Journal of Ambulatory Care Management

Analysis: Charge setting practices in the hospital sector (state-by-state breakdown over 10 years)

Analysis: Consumer use of health quality of care reporting

Analysis: Regional variations in health care costs

Comment Letter: FFY 2015 Medicare IPPS Proposed Rule

Comment Letter: Proposed Quality Reporting System (QRS) framework for rating Qualified Health Plans (QHP).

Comment Letter: FFY 2014 Medicare Inpatient Prospective Payment System Proposed Rule regarding the Disproportionate Share Hospital payments new uncompensated care distribution formula.

Comment Letter: FFY 2014 Medicare Inpatient Prospective Payment System Proposed Rule regarding Readmissions.

Comment Letter: FFY 2014 Medicaid Proposed Rule regarding the Medicaid Disproportionate Share Hospital Allotment Reductions.

Analysis: Assessing Medicare’s Readmission penalty calculation and the need to neutralize for high Medicaid and SSI effects and not to favor low volume hospitals.