Research partially funded by the JKTG Foundation recently appeared recently in the Bulletin of Mathematical Biology.
The research, Intermittent Hormone Therapy Models Analysis and Bayesian Model Comparison for Prostate Cancer, includes work by Heiko Enderling, Ph.D., a researcher with whom JKTG has worked on several projects.
As described in the published abstract, first-line therapy for prostate cancer includes androgen deprivation therapy (ADT), depriving both the normal and malignant prostate cells of androgens required for proliferation and survival.
In recent years, intermittent ADT has been proposed as an alternative to continuous ADT. Several mathematical models with different biological resistance mechanisms have been considered to simulate intermittent ADT response dynamics.
The research compares 13 intermittent dynamical models and assess their ability to describe prostate-specific antigen (PSA) dynamics.
I’d like to introduce the concept that coalescing or “convergent thinking” may be detrimental within an organizational setting. By this, I mean that individuals working in the same or similar space often tend to think similar thoughts.
One would think that research about climate issue is one area that people would come together and commit to doing it right – collaboratively, transparently and without ego.
The Medicare Trust Fund (TF) Annual Trustees report on solvency drives much of the discussion about Medicare payments. Therefore, it’s important and appropriate to understand the underpinnings of the report in order to best understand and engage in the discussion.